Secondary Research by Winning the Fight

Research on Arginine (Substance in AAKG Supplement in Deanna Protocol Plan)

Arginine Corrected Metabolic Dysfunction in Children with Mitochondrial Diseases

  • What this article proves: One of the substances in the Deanna Protocol Plan is arginine. Its purpose, along with Alpha ketoglutarate, is to deliver energy to the Kreb’s Cycle and, thereby, help the mitochondria function and prevent cells from dying. This piece of literature shows evidence that arginine is effective in correcting malfunctioning mitochondria.
  • Link: https://www.newswise.com/articles/intravenous-arginine-benefits-children-after-acute-metabolic-stroke?sc=mwhn
  • If link above is broken, look for article online using the title and the source.
  • The original title of the article is: Intravenous Arginine Benefits Children after Acute Metabolic Stroke
  • Source: Children’s Hospital of Philadelphia

Research on Bacteria and Neurodegenerative Diseases

ALS Patients Test Positive for Borrelia Infection

  • What this article proves: This article proves that ALS is likely caused by the bacteria that belongs to the genus borrelia. Up until now, borreila was only thought to be the cause of Lyme disease, but Dr. Tedone hypothesizes that it also causes ALS. The borrelia bacteria is very hard to detect in the body because, unlike other bacteria, the spirochete bacteria (spiral shaped bacteria) burrows into the soft tissue and is not present in the blood (other than red blood cells). Most tests for borrelia are inefficient at detecting bacteria in soft tissue.
  • Link: https://www.americanintegrative.com/wp-content/uploads/2016/06/ALS-and-LYme-I-am-pleased-to-announce-the-following.pdf
  • If link above is broken, look for email online using the title and the source.
  • The original title of the email is: I am pleased to announce the following
  • Source: American Integrative Pharmacy; Martin Atkinson-Barr PhD

News Article – Woman Diagnosed with MS Actually Had Borrelia Infection (Lyme Disease)

News Article – Massachusetts Woman Diagnosed with ALS Dies of Borrelia Infection (Lyme Disease)

  • What this article proves: The link between ALS and Borrelia
  • Link to original article> https://www.huffpost.com/entry/man-diagnosed-with-als-di_b_8891262
  • If link above is broken, look for article/study online using the title and the source.
  • The original title of is: Mother diagnosed with MS and facing life in a wheelchair is cured – after she discovered her symptoms were due to a TICK BITE
  • Source: DailyMail UK

Borrelia Infection in Multiple Sclerosis

  • Source: Alan McDonald, MD, FCAP – Dr. Paul H. Duray Research Fellowship Endowment, Inc
  • What these videos prove: Multiple Sclerosis is likely caused by a borrelia infection.
  • Link to Video 1: https://vimeo.com/166688480
  • If link above is broken, look for video online using the title and the source. The original title of the video is: Alan McDonald London Lecture May 2016
  • Link to Video 2: https://vimeo.com/user27613099
  • If link above is broken, look for video online using the title and the source.
  • The original title of the video is: London Lecture May 15 2016

Source: Dr. Alan MacDonald

Bacteria Found in Alzheimer’s Brain Post-Mortem

  • What this article proves: Alzheimer’s Disease, like ALS, is likely linked to bacterial infection with borrelia
  • Link to original video: https://vimeo.com/158001419
  • If link above is broken, look for article/study online using the title and the source.
  • The original title of article is: Final Lecture German Borreliosis Society Alan B MacDonald Lecture March 11 2016
  • Source: Alan MacDonald

Borrelia Detected in the Brains of Alzheimer’s Patients

  • What this article proves: The connection between borrelia bacteria and Alzheimer’s Disease
  • Link to original article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171359/
  • If link above is broken, look for article/study online using the title and the source.
  • The original title of article is: Alzheimer’s disease – a neurospirochetosis. Analysis of the evidence following Koch’s and Hill’s criteria
  • Source: Journal of Neuroinflammation
  • Author: Judith Miklossy

Borrelia Present in Alzheimer’s Disease

  • What this article proves: The connection between borrelia bacteria and Alzheimer’s Disease
  • Link to original article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171359/ 
  • If link above is broken, look for article/study online using the title and the source.
  • The original title of article is: Borrelia burgdorferi persists in the brain in chronic lyme neuroborreliosis and may be associated with Alzheimer disease.
  • Source: Journal of Alzheimer’s Disease
  • Author: Miklossy J1, Khalili K, Gern L, Ericson RL, Darekar P, Bolle L, Hurlimann J, Paster BJ.

Disulfiram Cures Borrelia Infection

  • What this article proves: Disulfiram Cures Borrelia Infection
  • Link to original article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627205/
  • If link above is broken, look for article/study online using the title and the source.
  • The original title of article is: Disulfiram (Tetraethylthiuram Disulfide) in the Treatment of Lyme Disease and Babesiosis: Report of Experience in Three Cases
  • Source: Antibiotics (Journal)
  • Author: Kenneth B. Liegner
  • Authors: Summer B. Gibson, Jonathan M. Downie, Spyridoula Tsetsou, Julie E. Feusier, Karla P. Figueroa, Mark B. Bromberg, Lynn B. Jorde, Stefan M. Pulst

Research on the Blood Brain Barrier

Blood Brain Barrier is impaired in ALS patients

  • What this article proves: This study shows that the BBB in someone with ALS does not function normally and certain substances that normally should not be able to pass through the BBB are able to pass through in those with ALS. This is significant because some substances in the Deanna Protocol cannot pass the BBB in healthy patients. However, in those with ALS, who have a malfunctioning BBB, the substances are able to pass through. This allows these substances to make a positive impact on patients with ALS. For the layperson: the blood brain barrier is a highly selective semipermeable border that separates the blood from the brain (BBB). The BBB “chooses” what substances are allowed to cross through to the brain and which are not. Many medications and substances introduced into the blood cannot pass the BBB, which means they cannot impact the brain and nervous system.
  • Link to original article: https://www.frontiersin.org/articles/10.3389/fncel.2014.00021/full
  • If link above is broken, look for article/study online using the title and the source.
  • The original title of is: Blood–CNS barrier impairment in ALS patients versus an animal model
  • Source: Frontiers in Cellular Neuroscience
  • Authors: Svitlana Garbuzova-Davis1,2,3* and Paul R. Sanberg

Blood Brain Barrier Breaks Down During Inflammation

  • What this article proves: The Blood Brain Barrier is not in tact when inflammation occurs
  • Link to original article: https://stm.sciencemag.org/content/9/397/eaai9111.full
  • If link above is broken, look for article/study online using the title and the source.
  • The original title of is: Glucose-regulated protein 78 autoantibody associates with blood-brain barrier disruption in neuromyelitis optica
  • Source: Science Translational Medicine: Neurobiology
  • Author: Fumitaka Shimizu1,*, Kristin L. Schaller2,*, Gregory P. Owens2, Anne C. Cotleur3, Debra Kellner3, Yukio Takeshita1, Birgit Obermeier3, Thomas J. Kryzer4, Yasuteru Sano1, Takashi Kanda1, Vanda A. Lennon4, Richard M. Ransohoff3,† and Jeffrey L. Bennett2,†

Research on Toxins and Neurodegenerative Disease

The articles below support Dr. Tedone’s point that toxins likely play a role in ALS and neurodegenerative disease. In 2009, when Dr. Tedone began his research, mainstream medicine did not accept that toxins play a role in ALS and the popular opinion was that non-genetic forms of ALS happened completely at random. Now, the role of toxins in ALS is documented and becoming more accepted in mainstream medicine. New research has given light to a new theory. According to Dr. Tedone and some others studying neurodegenerative diseases, borrelia bacteria is likely the real cause of neurodegenerative disease. Toxins are likely just an aggravator. What does this mean? Someone can have this bacteria in the body for a long time (even decades) without being sick because the immune system can keep the bacteria under control and prevent it from multiplying enough to cause disease. Dr. Tedone and his colleagues hypothesize that environmental factors (such as toxins and stress) can suppress the immune system and prevent it from keeping the bacteria under control. A suppressed immune system allows the bacteria that’s already there to multiply, attack the nervous system, and cause disease. While the studies below don’t address borrelia bacteria and its role in ALS, they do address the fact that toxins in the environment are strongly correlated with onset of neurodegenerative disease symptoms.

ALS from Mercury in Amalgam Fillings

  • What this article proves: A toxin, Mercury, could possibly be a cause of ALS, likely if the borrelia bacteria is already present in the body.
  • Link to original article here: https://www.ncbi.nlm.nih.gov/pubmed/28641283
  • If link above is broken, look for article/study online using the title and the source.
  • The original title of is: Healing of Amyotrophic Lateral Sclerosis: A Case Report
  • Source: Science Translational Medicine: Neurobiology
  • Author: Healing of Amyotrophic Lateral Sclerosis: A Case Report

Three Teachers in Same Classroom Suffer from ALS

  • What this article proves: ALS is only present in roughly .00595% of the American population (about 16,000 people out of the 270 million living in the U.S.). Due to the rarity of this disease odds of three unrelated teachers who worked in the same classroom all randomly contracting ALS by chance are extremely low. This leads to the probability that their ALS as brought on by an environmental cause. The full article is only available by paid subscription to medical research journals, but the abstract is here.
  • Link to original article here: https://www.ncbi.nlm.nih.gov/pubmed/3655851
  • If link above is broken, look for article/study online using the title and the source.
  • The original title of is: Three cases of amyotrophic lateral sclerosis in a common occupational environment
  • Source: Department of Neurology, Ohio State University Medical Center
  • Author: Hyser CL1, Kissel JT, Mendell JR.

Toxins in Blue Green Algae Can Cause Nerve Degeneration

  • What this article proves: This study proves that environmental factors such as toxins (and a particular toxin called BAMA in blue green algae) can cause neurodegenerative disease.
  • Link to article: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075376
  • If link above is broken, look for article/study online using the title and the source.
  • The original title of is: The Non-Protein Amino Acid BMAA Is Misincorporated into Human Proteins in Place of L-Serine Causing Protein Misfolding and Aggregation
  • Source: PLOS One Research Journal
  • Author: Rachael Anne Dunlop1, Paul Alan Cox2, Sandra Anne Banack2, Kenneth John Rodgers1*

Lead Exposure as a Risk Factor for ALS

  • Source: National Institute for Environmental Health Sciences
  • What this article proves: This article proves that lead exposure is linked to increase probability of ALS.
  • Link to article: https://www.ncbi.nlm.nih.gov/pubmed/16909025
  • If link above is broken, look for article/study online using the title and the source.
  • The original title of is: Lead Exposure as a Risk Factor for Amyotrophic Lateral Sclerosis
  • Author: Kamel, F; Umbach, DM; Hu, H; Munsat, TL; Taylor, JA; Sandler, JP

List of Toxins and How They Impact the Body

  • What this document proves: This document is a list of poisons known to cause neurological disease
  • Link to article: There is no link. This is a snippet from a medical book.
  • Book: Casarett & Doull’s Toxicology. The Basic Science of Poisons, 8th (2013).

Workplace Exposure to Toxins & ALS

Research on ALS & Genetics

The Evolving Genetic Risk for Sporadic ALS

  • What this article proves: There is a genetic component to sporadic ALS. Dr. Tedone believes it’s possible that the borrelia bacteria in ALS (when they reproduce) enter the cells and interrupt the energy cycle of the cell. In doing so, they cause gene mutations in the cell.
  • Link to original article: https://n.neurology.org/content/89/3/226
  • If link above is broken, look for article/study online using the title and the source.
  • The original title of article is: The evolving genetic risk for sporadic ALS

Source: American Academy of Neurology

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